Moringa Oleifera Extract Hinders the Cascades of Amiodarone Mediated Thyrotoxicosis in Albino Rats

Amiodarone AMD, a drug used in management of angina and refractory ventricular arrhythmia induces thyrotoxicosis in rat. The objective was to evaluate the role of Moringa Oleifera leaf methanolic exteract (MOE) administration and exposure to low doses of gamma-irradiation (LDR) as adjunctive strategy to modulate AMD associated thyrotoxicosis. The experiment started by rats i.p administration of AMD (100 mg/kg, b.wt./day ) and oral administration of MOE (250 mg/kg b. wt./day) for 10 and 15 consecutive days, respectively. While, the exposure to 0.5 Gy fractionated whole body gamma radiation was carried out among 2 fractions (0.25Gy on the 1 and 10 days of experiment). The thyroid profile (tri-iodothyonine; T3, thyroxine; T4 and Thyrotrophin; TSH) and the inflammatory indicator Interleukin 6 (IL6), in addition to the marker of thymus activity thymulin (TH) as well as, the hormones sensitive to thyroid secretion (Prolactin; PLR, Growth hormone; GH and Cortisol; COR) were determined in serum.The administration of MO extract and/or LDR to AMD rats significantly ameliorated the changes induced in Serum concentration of, thyroxine (T4), thyrotrophin (TSH), interleukin 6 (IL-6), thymulin (THY), prolactin (PLR), growth hormone(GH) and cortisol (COR). In conclusion, the administration of MO extract and/or LDR rats might provide substantial protection against amidorone-induced thyirotoxicosis and the subsequent undesirable bearing alterations.